Venom: Adds Poison Damage to the weapon provides Poison Resistance on armor increases Accuracy on jewelry.

Thunder: Adds Air Damage to the weapon provides Air Resistance on armor increases Dodging on jewelry.

Rock: Adds Earth Damage to the weapon provides Earth Resistance on armor increases maximum Vitality on jewelry.

Masterwork: Adds additional Physical Damage to the weapon provides additional Physical Resistance on armor increases maximum Magic Armor on jewelry.

Frost: Adds Water Damage to the weapon provides Water Resistance on armor increases Movement on jewelry.

Fire: Adds Fire Damage to the weapon provides Fire Resistance on armor increases Critical Chance on jewelry.

The effects increase in potency based on the rune's size. Each type of rune has set effects depending on whether it is applied to a weapon, armor , or an amulet/ring.

Enchanting is a subset of the crafting system in Original Sin 2, and a bit more complex than simply putting ingredients together until something happens. Here, players can use runes to imbue their gear with new effects, or amplify existing ones.

Divinity original sin 2 crafting guide